吕华（Lu, Hua）

研究兴趣:

高分子化学、可降解生物医用高分子材料、生物偶联、生物医药工程

教育经历:

• 2006 – 2011 博士, 美国伊利诺伊大学香槟分校材料系
• 2002 – 2006 学士，8868体育网页版入口

工作经历

• 2022 – 至今 博雅特聘教授，8868体育网页版入口
• 2020 – 至今 副主编，美国化学会期刊 Biomacromolecules
• 2020 – 2022 副教授（长聘），8868体育网页版入口
• 2014 – 2020 助理教授，8868体育网页版入口
• 2011 – 2014 博士后，Scripps研究所化学系

主要获奖及荣誉

• 中国化学会-英国皇家化学会青年化学奖（2023）
• 药明康德生命化学研究奖学者奖（2022）
• 国家杰出青年科学基金（2021）
• 北京大学青年教师基本大赛一等奖暨最受学生欢迎奖（2020）
• 中国化学会高级会员（2020）
• ACS PMSE Young Investigator（2020）
• 日本高分子学会（SPSJ）International Leading Young Scientist（2020）
• 中国化学会高分子青年学者奖（2019）
• 中国化学会青年化学奖（2017）
• 国家优秀青年科学基金（2017）

近五年代表论文

1. Haisen Zhou,† Guangqi Wu*,†, Zuo Zhang,† Zhen Zhu, Tanfeng Zhao, Qiankang Zhou, Haolin Chen, Zhenzhong Zhao, Yuanhao Dai, Xiaodong Jing, Wei Ji, Xuehai Yan, Lijiang Yang, Yiqin Gao, Huan Wang*, Hua Lu* “Data-driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies”, J. Am. Chem. Soc. 2025, 147, 21077–21088. (†equal contribution)
2. Ruichi Zhao,† Yangming Zhang,† Banlai Ruan, Hairuo Zhang, Niannian Lv, Jiayi Li, Yuhe R. Yang*, Xiaozhou Luo*, Hua Lu* “Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations”, Angew. Chem. Int. Ed. 2025, 64, e202425559. (†equal contribution)
3. Shuo Wang, Zi-You Tian, and Hua Lu*, “Recyclable Polythioesters and Poly(thioester-co-peptoid)svia Ring-Opening Cascade Polymerization of Amino Acid N-Carboxyanhydrides”, Angew. Chem. Int. Ed. 2024, 146, e202411630. 
4. Shuo Wang, Ming-Yuan Lu, Si-Kang Wan, Chun-Yan Lyu, Zi-You Tian, Kai Liu, and Hua Lu*, “Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and Mechanistic Insights”, J. Am. Chem. Soc. 2024, 146, 5678–5692. 
5. Jianhua Lu, Yuanhao Dai, Yahui He, Ting Zhang, Jing Zhang, Xiangmei Chen, Changtao Jiang, and Hua Lu*, “Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates”, J. Am. Chem. Soc. 2024, 146, 3974–3983. 
6. Guangqi Wu, Haisen Zhou, Jun Zhang, Zi-You Tian, Xingyi Liu, Shuo Wang, Connor W. Coley, and Hua Lu*, “A High-Throughput Platform for Efficient Exploration of Functional Polypeptide Chemical Space”, Nat. Synth. 2023, 2, 515-526. 
7. Y. Hu, Z.-Y. Tian, W. Xiong, D. Wang, R. Zhao, Y.Xie, Y.-Q.Song, J. Zhu, and H. Lu*; “Water-Assisted and Protein-Initiated Fast and Controlled Ring-Opening Polymerization of Proline N-Carboxyanhydride”, Natl. Sci. Rev. 2022, 9, nwac033.
8. Jianhua Lu, Zhun Xu, Hailin Fu, Yao Lin, Huan Wang, and Hua Lu*, “Room-Temperature Grafting from Synthesis of Protein–Polydisulfide Conjugates via Aggregation-Induced Polymerization”, J. Am. Chem. Soc. 2022, 144, 15709-15717. 
9. C. Dong†; G. Wu†; C. Chen; X. Li; R. Yuan; L. Xu; J. Zhang; H. Guo; J. Zhang; H. Lu*, and F. Wang*; “Site-specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e2021152. (†equal contribution) (Hot Paper). 
10. Z.-Y. Tian; Z. Zhang; S. Wang; and H. Lu*, “A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-Carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides”, Nat. Commun. 2021, 12, 5810.
11. W. Xiong; W. Chang; D. Shi; L. Yang; Z.-Y. Tian; H. Wang; Z. Zhang; X. Zhou; E.-Q. Chen,* and H. Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, 6, 1831-1843. (Highlighted by Chem)
12. J. Lu; H. Wang; Z.-Y. Tian; Y. Hou; and H. Lu*, “Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein-Polydisulfide Conjugates”, J. Am. Chem. Soc. 2020, 142, 1217-1221. (Selected as JACS Early Career Investigators Virtual Issue)