Prof. Lei has served as a guest editor to compile a special Symposium-In-Print on Bioorganic & Medicinal Chemistry to celebrate his 2017 Tetrahedron Young Investigator Award. http://www.sciencedirect.com/science/journal/09680896/25/11
Recently, Prof. Lei received 2017 Swiss Chemical Society Lectureship Award. He was invited to take a lecture tour and give several lectures in Switzerland. He visited University of Zurich, University of Geneva, EPFL, University of Basel, Syngenta and ETH. He is the first Chinese chemist received this very prestigious?award. Big congrats to Prof. Lei! News […]
Recently Prof. Lei ?received the 2017?KAIST School of Molecular Science Lectureship Award and gave a plenary lecture on natural product total synthesis and chemical biology at KAIST, South Korea.
Prof. Lei has won the prestigious 2017 Tetrahedron Young Investigator Award in ?Bioorganic and Medicinal Chemistry Prof. Xiaoguang Lei will give a plenary lecture at the?18th Tetrahedron Symposium, Budapest, Hungary, where?he will be formally presented with?his award. He also receives a certificate and an award of US $3,000. Additionally, a Symposium-in-Print in one of the […]
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be labeled with stable isotopes for quantitation. By locating the flexible proteins […]
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis Highlights Kongensin A (KA) is a potent inhibitor of necroptosis and an inducer of apoptosis KA inhibits necroptosis by preventing the activation of RIPK3 TQ ligation enables the identification of HSP90 as a cellular target of KA KA covalently binds to HSP90 […]
Reported is the first scalable synthesis of?rac-jungermannenones?B and C starting from the commercially available and inexpensive geraniol in 10 and 9 steps, respectively. The unique jungermannenone framework is rapidly assembled by an unprecedented regioselective 1,6-dienyne reductive cyclization reaction which proceeds through a vinyl radical cyclization/allylic radical isomerization mechanism. DFT calculations explain the high regioselectivity observed […]
Abstract: The increase and spread of Gram-negative bacteria resistant to almost all currently available β-lactam antibiotics is a major global health problem. The cause for drug resistance is primarily due to the acquisition of metallo-β-lactamases such as NDM-1. Aspergillomarasmine A (AMA), a fungal natural product, is an inhibitor of NDM-1 and has shown promising in […]
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congratulations to Lei Gao for Best poster Award at the 19th Tetrahedron Symposium
Congratulations to Lei Gao for Best poster Award at the 19th Tetrahedron Symposium
Small Molecule Enabled Chemical Biology and Drug Discovery
Lei, X.
Bioorganic & Medicinal Chemistry 25 (2017) 2815–2816
Prof. Lei has served as a guest editor to compile a special Symposium-In-Print on Bioorganic & Medicinal Chemistry to celebrate his 2017 Tetrahedron Young Investigator Award. http://www.sciencedirect.com/science/journal/09680896/25/11
Prof. Lei received the prestigious 2017 Swiss Chemical Society Lectureship Award!
Recently, Prof. Lei received 2017 Swiss Chemical Society Lectureship Award. He was invited to take a lecture tour and give several lectures in Switzerland. He visited University of Zurich, University of Geneva, EPFL, University of Basel, Syngenta and ETH. He is the first Chinese chemist received this very prestigious?award. Big congrats to Prof. Lei! News […]
Applying a chemoproteomic approach we uncovered a lot of novel bile acid interacting proteins
Recently, we have published a ACS Central Science paper, describing the?chemoproteomic profiling of bile acid interacting proteins.
Prof. Lei has received the 2017 KAIST School of Molecular Science Lectureship Award
Recently Prof. Lei ?received the 2017?KAIST School of Molecular Science Lectureship Award and gave a plenary lecture on natural product total synthesis and chemical biology at KAIST, South Korea.
Prof. Lei has received the prestigious 2017 Tetrahedron Young Investigator Award
Prof. Lei has won the prestigious 2017 Tetrahedron Young Investigator Award in ?Bioorganic and Medicinal Chemistry Prof. Xiaoguang Lei will give a plenary lecture at the?18th Tetrahedron Symposium, Budapest, Hungary, where?he will be formally presented with?his award. He also receives a certificate and an award of US $3,000. Additionally, a Symposium-in-Print in one of the […]
We have published a latest eLife paper to report the new CXMS method
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be labeled with stable isotopes for quantitation. By locating the flexible proteins […]
We have published a latest Cell Chemical Biology paper on necroptosis
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis Highlights Kongensin A (KA) is a potent inhibitor of necroptosis and an inducer of apoptosis KA inhibits necroptosis by preventing the activation of RIPK3 TQ ligation enables the identification of HSP90 as a cellular target of KA KA covalently binds to HSP90 […]
We report the first scalable total synthesis of tetracyclic diterpenoid jungermannenones B and C
Reported is the first scalable synthesis of?rac-jungermannenones?B and C starting from the commercially available and inexpensive geraniol in 10 and 9 steps, respectively. The unique jungermannenone framework is rapidly assembled by an unprecedented regioselective 1,6-dienyne reductive cyclization reaction which proceeds through a vinyl radical cyclization/allylic radical isomerization mechanism. DFT calculations explain the high regioselectivity observed […]
We report the first total synthesis and stereochemical configuration reassignment of aspergillomarasmine A
Abstract: The increase and spread of Gram-negative bacteria resistant to almost all currently available β-lactam antibiotics is a major global health problem. The cause for drug resistance is primarily due to the acquisition of metallo-β-lactamases such as NDM-1. Aspergillomarasmine A (AMA), a fungal natural product, is an inhibitor of NDM-1 and has shown promising in […]