Recently, Prof. Lei has received “Wei Shan Natural Product Synthesis” Award from Chinese Chemical Society. This award was set up in the memory of the late Prof. Wei-Shan Zhou for his remarkable achievements in natural product synthesis, and the goal of this award is to recognize the leading organic chemists in China who has made […]
Our latest Enantioselective Total Synthesis of (?)-Incarviatone A (JACS 2015, 137, 11946-11949) has been highlighted by C&E News. http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic […]
We have recently developed the second generation TQ-ligation, and demonstrated it as a powerful method to facilitate chemical biology studies. Second Generation TQ-Ligation for Cell Organelle Imaging Xiaoyun Zhang, Ting Dong, Qiang Li, Xiaohui Liu, Lin Li, She Chen, and Xiaoguang Lei* ACS Chem. Biol. 2015, DOI: 10.1021/acschembio.5b00193 ABSTRACT: Bioorthogonal ligations play a crucial role […]
Our latest discovery on the novel mode of action for a complex natural product has been highlighted by a news story on C&E News. Congratulations to Ting and Chao! “Chemists Explore Ways To Manipulate The Immune System” http://cen.acs.org/articles/93/i15/Chemists-Explore-Ways-Manipulate-Immune.html
Ting and Chao’s latest research breakthough on the chemical biology studies of complex natural product has been published on Nature Communications. Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Chen, X.; Li, L.; Cao, R.; Huang, N.; He, S.*; Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature […]
Prof. Lei recently received “2015 The Distinguished Lectureship Award” by Chemical Society of Japan (CSJ). He was invited to attend the CSJ annual meeting in Chiba, March 26-29 and present a keynote lecture entitled “Dissectin Cell Death with Complex Natural Products”. This prestigious award recognizes Prof. Lei’s remarkable contributions to the chemical biology studies of […]
-
-
-
-
-
-
-
-
-
-
Prof. Lei has received Roche Chinese Young Investigator Award of 2015
Prof. Lei recently received Roche Chinese Young Investigator Award of 2015. He was invited to give a lecture on the 3rd Roche-RSC symposium. ?
Prof. Lei has received “Wei Shan Natural Product Synthesis” Award
Recently, Prof. Lei has received “Wei Shan Natural Product Synthesis” Award from Chinese Chemical Society. This award was set up in the memory of the late Prof. Wei-Shan Zhou for his remarkable achievements in natural product synthesis, and the goal of this award is to recognize the leading organic chemists in China who has made […]
Our latest total synthesis has been highlighted by C&E News
Our latest Enantioselective Total Synthesis of (?)-Incarviatone A (JACS 2015, 137, 11946-11949) has been highlighted by C&E News. http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html
We have accomplished the first total synthesis of (-)-incarviatone A
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic […]
We had a wonderful soccer game and a mini-symposium with Prof. Wang’s group
We have developed the second generation TQ-Ligation
We have recently developed the second generation TQ-ligation, and demonstrated it as a powerful method to facilitate chemical biology studies. Second Generation TQ-Ligation for Cell Organelle Imaging Xiaoyun Zhang, Ting Dong, Qiang Li, Xiaohui Liu, Lin Li, She Chen, and Xiaoguang Lei* ACS Chem. Biol. 2015, DOI: 10.1021/acschembio.5b00193 ABSTRACT: Bioorthogonal ligations play a crucial role […]
Our latest research work has been reported by C&E News
Our latest discovery on the novel mode of action for a complex natural product has been highlighted by a news story on C&E News. Congratulations to Ting and Chao! “Chemists Explore Ways To Manipulate The Immune System” http://cen.acs.org/articles/93/i15/Chemists-Explore-Ways-Manipulate-Immune.html
Uncovered the mode of action for ainsliadimer A
Ting and Chao’s latest research breakthough on the chemical biology studies of complex natural product has been published on Nature Communications. Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Chen, X.; Li, L.; Cao, R.; Huang, N.; He, S.*; Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature […]
Prof. Lei received 2015 The Distinguished Lectureship Award by CSJ
Prof. Lei recently received “2015 The Distinguished Lectureship Award” by Chemical Society of Japan (CSJ). He was invited to attend the CSJ annual meeting in Chiba, March 26-29 and present a keynote lecture entitled “Dissectin Cell Death with Complex Natural Products”. This prestigious award recognizes Prof. Lei’s remarkable contributions to the chemical biology studies of […]
Celebration party, 2015/1/31
We have a celebration party for Weilong and Jing’s significant breakthroughs in complex natural product syntheses!